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  • Multicellular senescence impairs skeletal muscle recovery following disuse in aging

    Paul-Emile Bourrant, Elena M Yee, Zachary J Fennel, Robert J Castro, Chad M Skiles, Jonathan J Petrocelli, Naomi M M P de Hart, Lisa A Lesniewski, Anna E Beaudin, Katsuhiko Funai, Christopher S Fry, Micah J Drummond

    Sci Adv. 2026 May 29;12(22):eaed5255
    Epub 2026 May 27

    PUBMED

  • Robust immune cell infiltration and macrophage senescence occur within a week of recovery after limb immobilization in older adult skeletal muscle

    Chad M Skiles, Zachary J Fennel, Paul-Emile Bourrant, Elena M Yee, Robert J Castro, Hannah A Zabriskie, Melina Itinose, Mark A Supiano, Ryan M O'Connell, Micah J Drummond

    J Physiol. 2026 Apr;604(8):3379-3395
    Epub 2026 Mar 27

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  • Macrophage metabolic rewiring rejuvenates muscle Raman signatures and cellular remodeling during regrowth in aged mice

    Zachary J Fennel, Negar Kosari, Paul-Emile Bourrant, Elena M Yee, Robert J Castro, Anu S Kurian, Jonathan Palmer, Morgan Christensen, Katsuhiko Funai, Ryan M O'Connell, Anhong Zhou, Micah J Drummond

    JCI Insight. 2025 Sep 9;10(20):e194303
    eCollection 2025 Oct 22

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  • Disuse-induced muscle fibrosis, cellular senescence, and senescence-associated secretory phenotype in older adults are alleviated during re-ambulation with metformin pre-treatment

    Jonathan J Petrocelli, Alec I McKenzie, Naomi M M P de Hart, Paul T Reidy, Ziad S Mahmassani, Alexander R Keeble, Katie L Kaput, Matthew P Wahl, Matthew T Rondina, Robin L Marcus, Corrine K Welt, William L Holland, Katsuhiko Funai, Christopher S Fry, Micah J Drummond

    Aging Cell. 2023 Nov;22(11):e13936.
    Epub 2023 Jul 24.

    pubmed
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